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This is aclear gain of oncogenic function, as p53-null cells show higher levels of chemokineexpression compared to cells expressing wild-type p53, yet substantial increases inchemokine expression occur when GOF p53 proteins are present [ 21 ]. This results in a coefficient of 1.0 (and, whenmultiplied by 100, is 100 percent agreement).

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Words are used very precisely and ambiguity is avoided whereverpossible (Crystal, 1997). These symptoms are transient and canbe controlled with corticosteroids and reassurance

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